Transcription factors prediction


A transcription factor (TF) is a sequence-specific DNA-binding protein that modulates the transcription of a set of particular genes, and thus regulates gene expression in the cell. TFs have commonly been predicted by analyzing sequence homology with the DNA-binding domains of TFs already characterized.

A transcription factor (TF) is a sequence-specific DNA-binding

A DNA-binding domain (DBD) is an independently folded protein domain that contains at least one structural motif that recognizes double- or single-stranded DNA. A DBD can recognize a specific DNA sequence (a recognition sequence) or have a general affinity to DNA. › wiki › DNA-binding_domain

protein that modulates the transcription of a set of particular genes, and thus regulates gene expression in the cell. TFs have commonly been predicted by analyzing sequence homology with the DNA-binding domains of TFs already characterized.Dec 28, 2020


What is the primary function of transcription factors?

What are the 4 steps of transcription?

  • Initiation. The DNA molecule unwinds and separates to form a small open complex.
  • Elongation. RNA polymerase moves along the template strand, synthesising an mRNA molecule.
  • Termination. In prokaryotes there are two ways in which transcription is terminated.
  • Processing.

What is the best transcription program?

What is the Best Transcription Software?

  • 1. Best overall transcription software ($1.25 per minute). …
  • 3. Trint. Transcribe is a privacy-focused transcription tool that’s suitable for converting audio files to text automatically.
  • 4. Descript. …
  • 5. Express Scribe. …
  • 6. Inqscribe. …
  • 7. Otter. …
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What are some examples of transcription factors?

What are five examples of genetic factors?

  • Down Syndrome. Typically, the nucleus of an individual cell contains 23 pairs of chromosomes, but Down syndrome occurs when the 21st chromosome is copied an extra time in all or …
  • Thalassemia.
  • Cystic Fibrosis.
  • Tay-Sachs disease.
  • Sickle Cell Anemia.
  • Learn More.
  • Recommended.
  • Sources.

What role does a transcription factor play?

These mechanisms include:

  • stabilize or block the binding of RNA polymerase to DNA
  • catalyze the acetylation or deacetylation of histone proteins. The transcription factor can either do this directly or recruit other proteins with this catalytic activity. …
  • recruit coactivator or corepressor proteins to the transcription factor DNA complex

How do transcription factors determine cell fate?

When new cell fates are induced during embryonic development, tissue regeneration or cell reprogramming, regulatory transcription factors must suppress genes specific to the original cell fate and activate genes specific to the new cell fate.

What is the main idea of transcription factors?

Transcription factors are proteins involved in the process of converting, or transcribing, DNA into RNA. Transcription factors include a wide number of proteins, excluding RNA polymerase, that initiate and regulate the transcription of genes.

What are the 4 transcription factors?

The four transcription factors OCT4, SOX2, KLF4, and MYC (OSKM) together can convert human fibroblasts to induced pluripotent stem cells (iPSCs). It is, however, perplexing that they can do so only for a rare population of the starting cells with a long latency.

What are the 5 transcription factors?

General transcription factors are involved in the formation of a preinitiation complex. The most common are abbreviated as TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIIH. They are ubiquitous and interact with the core promoter region surrounding the transcription start site(s) of all class II genes.

How do transcription factors increase gene expression?

Transcription factors are proteins that help turn specific genes “on” or “off” by binding to nearby DNA. Transcription factors that are activators boost a gene’s transcription. Repressors decrease transcription.

What is the role of transcription factors quizlet?

What is the role of transcription factors? Transcription factors are required for RNA pol II binding to promoter. TFs are DNA binding proteins, but can also bind other TFs. They assist in bringing RNA pol II in close proximity of the promoter.

Does p53 act as a transcription factor?

Abstract. p53 is a transcription factor that suppresses tumor growth through regulation of dozens of target genes with diverse biological functions.

What are the four letters most commonly used to represent the transcription factors used in cell reprogramming?

Introduction of four transcription factors, Oct3/4, Sox2, Klf4, and c-Myc, can successfully reprogram somatic cells into embryonic stem (ES)-like cells.

What is a Transcription Factor Binding Site?

To begin, we need to define a transcription factor (TF). A TF is a protein that can bind to DNA and regulate gene expression. The region of the gene to which TF binds is called a transcription factor binding site. These sites are a subset of DNA binding sites.

How Do Transcription Factor Binding Sites Work?

Transcription factor binding sites are a part of either the promoter or enhancer region of a gene. A gene promoter sits upstream to a gene and contains three important regions. These are the regulatory protein binding site, the transcription factor binding site, and the RNA polymerase binding site.

How Do We Find Transcription Factor Binding Sites?

There are many ways to figure out if a particular piece of DNA is or has a transcription factor binding site within it. You can actually do a browser search for several different programs which will analyze a stretch of DNA sequence.

What is transfac in biology?

TRANSFAC. It is a database of eukaryotic transcription factors, their DNA binding profiles, and genomic binding sites [2]. TRANSFAC consists of information about transcriptional regulation that can help in predicting potential transcription factor binding sites in DNA sequences. However, this is not freely accessible.

What is TFsitescan?

Tfsitescan is an online predictor of transcription factor binding sites in DNA sequences [6]. It works best with sequences consisting of around 500 nucleotides. Users can search for mammalian sites, prokaryotic sites, amphibian sites, yeast, avian, drosophila, and many other sites. It is freely available at


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